Abstract: In order to improve design efficiency and design level of manufacturing enterprise, a design frame based on knowledge for high speed spindle system design was proposed. A knowledge modeling method based on ontology was adopted, and knowledge reuse was realized. The key technologies of the system, such as rules knowledge description, facts knowledge description and knowledge processing templates were applied in the spindle system design of the platform. The system integrated the main axle design experience, knowledge and process to realize the knowledge sharing, and helped the designer effectively complete the intelligent design of the spindle system.