Abstract: The deepening of economic globalization brings along educational internationalization.The smooth construction of China-ASEAN Free Trade Area and the implementation of the Bridgehead Construction Strategy in Yunnan facilitate educational exchanges and cooperation between Yunnan and five countries in the Greater Mekong Sub-region.Since Honghe College has been upgraded to a university, it has actively carried out exchanges and cooperation with Vietnamese educational institutions, research institutes and governmental organizations for eight years.It has gradually formed all-round, multi-level and extensive exchanges and cooperation, with language training as a key, scientific research cooperation as a platform, educational cooperation as the core, cultural and sports exchange as the link.This paper, taking Honghe University as a case study, analyzes the model of educational cooperation between Yunnan and GMS countries.