N-(4-异丙基苯甲酰基)-4-甲基哌啶水溶性液剂的制备及其抑菌活性研究

Preparation of Water-soluble Liquid of N-(4-isopropylphenyl) -4-methyl Piperidine and Research on Its Antifungal Activity

摘要: 以对异丙基苯甲酸和4-甲基哌啶为原料，采用酰氯胺解法合成一种具有抑菌活性的新型化合物N-(4-异丙基苯甲酰基)-4-甲基哌啶，并用¹H NMR和¹³C NMR对其结构进行表征。将其制成水溶性液剂，并以水稻纹枯病菌、小麦赤霉病菌、玉米小斑病菌、油菜菌核病菌、番茄灰霉病菌、马铃薯晚疫病菌、瓜类炭疽病菌、葡萄白腐病菌、柑橘绿霉病菌和苹果轮纹病菌等10种病原真菌为靶标对其抑菌活性进行研究。结果显示，该制剂性能稳定，具有较好的抑菌效果。

Abstract: 4-isopropyl benzoic acid and 4-methylplperidine was taken as raw materials and a new compound N-(4-isopropylphenyl)-4-methyl piperidine with antifungal activity was synthesized by acyl chloride aminolysis. The compound structure was characterized by means of ¹H NMR and ¹³C NMR. Meanwhile, its water-soluble liquid was prepared and its antifungal activity was evaluated against Rhizoctorzia solani, Fusarium graminearum, Helminthosporium maydis, Sclerotinia sclerotiorum, Botrytis cinerea, Phytopthora infestans, Colletotrichum lagenarium, Coniella diplodiella, Penicilium digitatum Sacc and Physalospora Piricola. Results showthat its performance is stable and it has good antifungal activity.