Abstract: Under the premise of using the experience and knowledge, a select method of drive mode of spindle system based on fuzzy design rules is proposed. It involves applying fuzzy theory according to main steps of drive mode selection of machine tools. Integrated drive strategy to the spindle system of intelligent design, better results is achieved through practical application in a large machine tools manufacture, the feasibility and practicability of proposed system principles and implementation techniques is indicated, and the better design quality and higher efficiency is showed.