Abstract: Differential floating transmission seal is the key component of a centrifuge, whose main role is the delivery of fluid pressure and pushes the rod to move back and forth.Because of poor environment and the special structure, the seal corrosion easily occurs and sealing failure follows.The electrochemical corrosion, stress corrosion and face erosion are serious.In this paper, according to on-scene investigation and comparison of real object, the corrosion mechanism, conditions, characteristics and development are analyzed, and the specific methods and measures for preventing the occurring of the corrosion are put forward.All these provide reference for solving or improving the corrosion problem of differential float transmission seal.