Abstract: Infilled wall frame structure is widely used in China at present. It can be used not only to separate the housing space, but also to greatly affect the structural dynamic characteristics. Considering the infilled wall and the frame structure working together, the structure's response under the earthquake is simulated. In this paper, taking the stiffness, strength degradation and pinching effect of structural elements together into account, the authors adopt Reinborn-Valle damage model to conduct damage analysis. And two aspects are considered, i.e., one with infilled wall and another without infelled wall for an infilled wall frame structure, which is planned to build in Dujiangyan under strong earthquake. The results show that infilled wall damage and the author suggested that in the established as the first line of Anti-seismic defense structure shall be fully considered.