Abstract: This article choses single compression stage of the self-developed YQH-100 oil-gas helico-axial multiphase pump as research object, with combination of mixture model and standard k-ε turbulence model, and based on the given 9 programs around semi-cone angle rotor and staticvane hubs of multiphase pump ranging from 4.08° to 12°. The numerical simulation is carried out in 5 operating conditions with the gas volume fraction(GVF) of 0, 10%, 30%, 50% and 70%. Because of the similar simulation results, we analyze the characteristic of the semi-coneangleof hub in 4.08°, 6°, 8°, 10° and 12°.The results showed that as the semi-cone angle of hub increases, the head of the rotorvane decreases firstly and then increases, and the hydraulic loss of the staticvane increases continuously. The head of the multiphase pump decreases firstly, then increases and decreases finally. The shaft power gradually decreases and the efficiency gradually increases. The maximum difference of the head is 3.04 meters and the maximum efficiency difference is 7.24% on average.As the semi-cone angle of hub increases, the back-flow at the outlet of the rotor vane decreases, and more uniform distribution of gas within the rotor vane, vortex flow increases in the staticvane channel.