Abstract: Chengdu, as an important growth pole in the west and a core member of Chengdu-Chongqing Economic Circle, is accelerating the construction of digital economy innovation and development pilot zone. This paper first analyzes the coupling mechanism between digital economy and high-quality development of manufacturing industry, and builds the corresponding evaluation index system, and then makes comparison between Chengdu and Beijing, calculates the comprehensive index of digital economy and high-quality development of manufacturing industry in two regions by entropy method, analyzes the dynamic characteristics of the coupling and coordinated development between digital economy and high-quality development of manufacturing industry in the two cities. The study finds that, theoretically, digital economy promotes high-quality development of manufacturing industry by improving economic benefits, promoting green development, inducing technological innovation and increasing social benefits. The empirical results show that the comprehensive level of digital economy and high-quality development of manufacturing industry in Chengdu is generally on the rise, and they have reached the intermediate coordination stage, but compared with Beijing, they still need to be improved. Based on this, the paper suggests that Chengdu learn from the relevant experience of Beijing and other cities, strengthen the integration of digital economy and manufacturing industry to achieve high-quality coordination between the two.