Abstract: Excellent employees are the foundation and strength of enterprises and organizations.How to improve the effectiveness of human resource practice has become an academic focal point in the field of human resource management. Drawing on the social information processing theory, this study investigates the impact of a high-performance work system(HPWS) on performance, and incorporates employees’ perception of HPWS, perceived organizational support and power distance into the theoretical model, and then constructs a moderated chain mediation model. Based on the samples of 436 enterprises participants in the main city of Hunan, Sichuan, Hubei and other provinces in China, this study does an empirical test with structural equation modeling (SEM), bootstrap and Latent Moderate Structure Equation. The analysis reveals that when manager’s implemented HPWS is consisted with employee perception of HPWS, the system can turn into more perceived organizational support and better performance. However, in the course of performance transformation, power distance affects the mediation effect of employee’s perception of HPWS and perceived organizational support in the relationship between manager’s implemented HPWS with employee performance.