Abstract: The coordinated development of the digital economy and urban ecological resilience is one of the effective ways to promote the high-quality development of urbanization and the construction of beautiful cities. This study examines the interplay between digital economy growth and urban ecological resilience in the Pearl River Delta region from 2012 to 2021. Utilizing a combination of entropy weight method, TOPSIS model, coupled coordination model, and PLSR model, it constructs an evaluation index system to analyze the spatial-temporal dynamics, coupling coordination, and influence relationship between these two factors. The findings reveal: (1) a transformation in digital economy development characterized by a slow phase followed by a rapid growth phase, primarily driven by policy guidance, with an “echelon” pattern of development across cities; (2) urban ecological resilience displaying a spatial trend of being higher in central areas and lower in peripheral ones, with Guangzhou, Shenzhen, and Dongguan leading in resilience levels; (3) a significant positive impact of digital economy development on enhancing urban ecological resilience, with variations among cities, and digital infrastructure and industrialization being key contributors; (4) the coupling coordination between digital economy and ecological resilience mostly shows a pattern of two cities outperforming others, with only Guangzhou and Shenzhen reaching a high level of coupled coordination. The study suggests that future strategies in the Pearl River Delta should focus on leveraging policy guidance to boost digital economy in lesser-developed cities, utilizing ecological strengths to build unique industries, and emphasizing the central cities’ role in fostering coordinated digital and ecological development.